A glutathione responsive nanoplatform made of reduced graphene oxide and MnO2 nanoparticles for photothermal and chemodynamic combined therapy

Based on the specific tumor microenvironment, characterized by an overproduction of H2O2 and a high glutathione (GSH) concentration, cascade reactions nanomaterials, capable mediating GSH depletion reactive oxygen species (ROS) generation, have become popular strategy to increase cancer therapy efficiency. In this study, we exploited reduced graphene oxide (rGO), one most promising graphene-based materials, in combination with manganese dioxide nanoparticles (MnO2 NPs) design multifunctional nanoplatform ([email protected]2) for efficient photothermal/chemodynamic combined therapies. MnO2 NPs were anchored onto surface rGO nanosheets (rGO NSs). oxidize intracellular GSH, generated Mn2+ ions converted into HO Fenton reaction. Meanwhile, NSs mediated photothermal (PTT) could further kill cells. High temperature caused conversion increased reaction rate, which enhanced efficiency chemodynamic (CDT). Importantly, thanks cell uptake favored delivery properties rGO, [email protected]2 possessed higher lethality The decrease nanomaterials’ effective dose would improve biosecurity reduce cost. Therefore, great potential exploiting synergistic effect PTT photothermal/delivery CDT.